Thank you Jeff and Dayle.
Jeff please tell me what your settings are. Are you using 3.3.5.17625 as LM latest version? Do you have FSUIPC, and Active Sky Next? I have literally spent days trying to figure this out. It seems that when I shut down the computer overnight that somehow the registry key or something happens that requires me to re-install IS3 and then once I have to reboot P3D I have to re-install the module. I have tried to install all the simconnects I could find. I did find a reference in the SDK that says that P3D doesn't even use simconnect except if you had a remote computer. I have looked the dll.xml in the roaming and the dll.xml in the program data for clues. There is no doubt that once the bootstrap file loads for Active Sky Next that it hijacks the simconnect because IS3 will not load with any of the above tricks. I'm willing to try about anything.
Thanks again for your responses.
Tom